Before taking this medicine
You should not use Promethazine with Codeine if you are allergic to codeine or promethazine, or if you have:
- asthma or severe breathing problems;
- a stomach or bowel obstruction(including paralytic ileus);
- narrow-angle glaucoma; or
- if you are unable to urinate.
Do not use this medicine if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, raagiline, selegiline, tranylcypromine, and others.
Promethazine with Codeine is not approved for use by anyone younger than 12 years old.
Usual Adult Dose for Promethazine Cough
Promethazine 6.25 mg/ Codeine 10 mg per 5 mL:
Average effective dose: 5 mL orally every 4 to 6 hours as needed
Maximum dose: 30 mL (promethazine 37.5 mg; codeine: 60 mg) in 24 hours
-Liquid preparations should be measured with an accurate milliliter measuring device.
Uses: Temporary relief of coughs and upper respiratory symptoms associated with allergy or the common cold.
Renal Dose Adjustments
Use with caution, especially in patients with severe renal impairment
Liver Dose Adjustments
Use with caution, especially in patients with severe hepatic impairment
Elderly: Use with caution generally starting at the lower end of the dosing range.
This combination medication is used to treat symptoms caused by the common cold, flu, allergies, or other breathing illnesses (e.g., sinusitis, bronchitis). Promethazine is an antihistamine that relieves watery eyes, itchy eyes/nose/throat, runny nose, and sneezing. Codeine is an opioid cough suppressant (antitussive) that affects a certain part of the brain, reducing the urge to cough.